Diabetes Drugs: Invokana

SGLT2 Inhibitors

Invokana is an SGLT2 (sodium-glucose cotransporter-2) inhibitor. SGLT2 inhibitors are prescription medicines approved by FDA to treat type 2 diabetes. In combination with diet and exercise, SGLT2 inhibitors are designed to lower blood sugar levels.

How Do SGLT2 Inhibitors Like Invokana Work?

SGLT2 inhibitors lower blood sugar (glucose) by stopping glucose from being reabsorbed. SGLT2 is a protein that helps the kidneys process sugar so it can be reabsorbed into the bloodstream. SGLT2-inhibitors, as their name suggests, block that reabsorbing, so more glucose is flushed out of the body in urine. Other diabetes drugs control blood sugar by acting on the pancreas or on insulin levels. SGLT2-inhibitors are unique in that they go to work in the kidneys.

Specific SGLT2 inhibitors are (brand name/generic name):

  • Invokana (canagliflozin)
  • Invokamet (canagliflozin and metformin)
  • Farxiga (dapagliflozin)
  • Xigduo XR (dapagliflozin and extended-release metformin)
  • Glyxambi (empagliflozin and linagliptin)

Invokana is Associated with Dangerous Medical Issues

Since the FDA approved the use of SGLT2 inhibitors to treat type-2 diabetes, it has issued warnings about several alarming and dangerous medical issues that have been reported in association with the drugs. Invokana now carries warnings for:

  • Diabetic ketoacidosis (DKA)
  • Urosepsis, a life-threatening blood infection
  • Pyelonephritis, a serious kidney infection that starts as a urinary tract infection (UTI)
  • Increased risk of toe, foot, and leg amputations

Diabetic ketoacidosis (DKA) is serious medical condition that can result in coma or death. It occurs when the body does not get enough glucose because of insufficient insulin. When that occurs, the body burns fat instead of sugar for energy. Burning fat produces ketones as chemical waste. Ketones are a type of acid.

When ketone levels are too high, it is toxic and can poison the body. Symptoms of ketoacidosis are:

  • Abdominal pain
  • Unusual sleepiness or fatigue
  • Nausea or vomiting
  • Difficulty breathing

Contact Us

DKA is a condition that requires immediate urgent medical attention.

Urinary tract infections (UTIs) and yeast infections occur in about 4 to 11 percent of patients taking an SGLT2 inhibitor. These infections can escalate into serious blood and kidney infections that require hospitalization. Data has indicated that Invokana and Farxiga may be associated with an increased risk of acute kidney injury.

What Is Type 2 Diabetes?

Type 2 diabetes is the most common kind of diabetes. It is also called noninsulin-dependent diabetes and used to be called adult-onset diabetes, but with an increase in childhood obesity, type-2 diabetes is increasingly seen in children as well as adults. It is a chronic condition that affects the body’s ability to process glucose (sugar) to create energy. In type-2 diabetes, either the body doesn’t produce enough insulin, the hormone that regulates the movement of sugar into the cells, or it is resistant to the effects of insulin. There is no cure, but type-2 diabetes can often be controlled with diet and exercise. However, when diet and exercise fail, medicine may be necessary.

Report Diabetic Ketoacidosis, Amputation, or Kidney Damage Due to Invokana

If you or a loved one experienced DKA or kidney damage while taking Invokana or required an amputation, you may be entitled to compensation to cover medical bills, time off from work or loss of work, and emotional pain and suffering.

Contact us for a free consultation. Our attorneys have years of experience and a reputation for personalized, compassionate partnering with our clients. We also have the expertise, resources, and manpower to fully investigate your circumstances in order to get you the justice you deserve.

You pay nothing unless we win your case. Call us at 516-746-7000 or fill out the form on this page and someone will contact you shortly.

Important: Consult your doctor before stopping any prescribed medication.